In Dupuytren disease, fibrosis usually begins in the palm of the hand and extends to the fingers (the most common involved finger is the ring finger, followed by the little finger, thumb, middle finger and index finger, respectively). Dupuytren leads to abnormal flexion of the fingers, involvement of the metocarpophalangeal joints (MCP) and proximal interphalangeal joints (PIP) and can also involve the distal interphalangeal joint (DIP). Dupuytren disease usually progresses gradually over the years and is irreversible. The disease was discovered by Felix Plotter in 1614, yet later attributed to Baron Guillaume Dupuytren, a French physician in 1831. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease.ĭupuytren disease is a benign fibroproliferative disorder that results in the formation of collagen knots and fibres in the palmar fascia. The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. The results of meta-regression revealed a decreasing trend in the prevalence of Dupuytren disease by increasing the sample size and the research year ( P < 0.05). According to the subgroup analysis, in terms of underlying diseases, the highest prevalence was obtained in patients with type 1 diabetes with 34.1% (95% CI 25–44.6%).
The highest prevalence rate is reported in Africa with 17.2% (95% CI 13–22.3%). Resultsīy evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.7–11.7%).
#COMPREHENSIVE META ANALYSIS 3.3 SOFTWARE#
Data analysis was performed within the Comprehensive Meta-Analysis Software version 2.0. In order to analyse reliable studies, the stochastic effects model was used and the I 2 index was applied to test the heterogeneity of the selected studies. Subsequently, SID, MagIran, ScienceDirect, Embase, Scopus, PubMed and Web of Science databases and Google Scholar search engine were searched without a lower time limit and until June 2020. The search keywords were Prevalence, Prevalent, Epidemiology, Dupuytren Contracture, Dupuytren and Incidence. In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. The previous studies reveal different levels of Dupuytren’s prevalence worldwide hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally. The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia.
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